General Cell Based Assays
Eurofins Discoverx PathHunter eXpress ACVRL1/ACVR2 Dimerization Assay, 2pl Kit. (93-0963E3CP0M)
The PathHunter ACVRL1/ACVR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR2 target protein fused to PK alongside ACVRL1 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Rat Leptin ASY 25 PL
The Meso Scale Discovery U-PLEX Rat Leptin Assay Kit is a multiplex immunoassay that measures leptin levels in rat serum plasma and cell culture supernatants The assay uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This kit includes a 96-well plate coated with capture antibodies detection antibodies labeled with MSD SULFO-TAG calibrators and controls The assay has a lower limit of detection of 1 3 pg/mL and an upper limit of quantification of 10 000 pg/mL for leptin
ABclonal Technology Somatostatin Receptor 2 SSTR2
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney
Eurofins Discoverx InCELL Hunter eXpress HCK Kinase Binding Assay, 10pl Kit. (96-0041E15CP0L)
The InCELL Hunter eXpress HCK Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of HCK via detection of HCK levels. This product uses EFC technology. The cell line included overexpresses HCK target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Sigma Aldrich Fine Chemicals Biosciences alpha Glucosidase Activity
Glucosidase hydrolyzes carbohydrates by acting on terminal non-reducing a(1A†4)-linked D-glucose residues with the release of D-glucose. Defects in glucosidase have been implicated in Pompe disease and diabetes.
Eurofins Discoverx PathHunter eXpress IFNGR1/IFNGR2 Dimerization Assay, 10pl Kit. (93-1098E3CP5L)
The PathHunter IFNGR1/IFNGR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IFN-g) induced dimerization of IFNGR1/IFNGR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNGR1 target protein fused to PK alongside IFNGR2 target protein fused to EA. Upon ligand-induced dimerization of IFNGR1/IFNGR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MC1R U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0861E3CP5L)
The PathHunter MC1R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. α-MSH) based activation of MC1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MC1R and EA-tagged β-Arrestin-2. Activation of MC1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 500 Assay Points
HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 50,000 Assay Points
HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 50,000 Assay Points
Revvity Health Sciences Inc HTRF Human Phospho-ULK1 (Ser758) Detection Kit, 500 Assay Points
HTRF Human Phospho-ULK1 (Ser758) Detection Kit, 500 Assay Points
Sigma Aldrich Fine Chemicals Biosciences Cell Counting Kit - 8, for quantitation of viable cell number in proliferation and cytotoxicity assays | 100 tests
Cell Counting Kit - 8, for quantitation of viable cell number in proliferation and cytotoxicity assays | 100 tests
Selleck Chemical LLC KC7F2 20mg 927822-86-4
KC7F2 is a selective HIF-1? translation inhibitor with IC50 of 20 ?M in a cell-based assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Revvity Health Sciences Inc HTRF Human Total CDK6 Detection Kit, 500 Assay Points
HTRF Human Total CDK6 Detection Kit, 500 Assay Points
Eurofins Discoverx PathHunter eXpress mOPRD1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0611E2MCP0L)
The PathHunter mOPRD1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. DADLE) based activation of mOPRD1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mOPRD1 and EA-tagged β-Arrestin-2. Activation of mOPRD1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human Phospho-IRF3 (Ser386) Detection Kit, 10,000 Assay Points
HTRF Human Phospho-IRF3 (Ser386) Detection Kit, 10,000 Assay Points